FAD-dependent H3K4me/H3K4me3 demethylase activity [GO_0140682]
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
FAD-dependent H3K4me/H3K4me3 demethylase activity
ID: GO_0140682
Class
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.
Open in VFB 3D Browser →Classification
- histone H3K4 demethylase activity
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Alternative Names
| Synonym | Scope | Reference |
|---|---|---|
| histone H3K4me2 demethylase activity | broad synonym | |
| histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity | exact synonym | |
| histone H3K4me demethylase activity | related synonym |
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